Shock and awe: unleashing the heat shock response to treat Huntington disease.

Cellular Model of Huntington Disease a Exacerbates Inclusion Body Formation in Heat Shock Response Activation

Expression of Regulated Oncogen-Alpha by Primary Hepatocytes Following Isolation and Heat Shock Stimulation

High levels of regulated oncogen-alpha (GRO-a) expression have been observed in the liver. GRO-a stimulates proliferation of epithelial cells and induction of rolling and extravascular migration of neutrophils and mononuclear cells. Given the above observations, this chemokine was chosen to be analyzed in freshly isolated and cultured hepatocytes. In this study, hepatocytes (2×106 cell/ml) were...

The Dynamic and Vibration Response of Composite Cylindrical Shell Under Thermal Shock and Mild Heat Field

In this article, the vibration and dynamic response of an orthotropic composite cylindrical shell under thermal shock loading and thermal field have been investigated. The problem is that the shell is initially located at a first temperature, and some tension caused by a mild heat field is created, then the surface temperature of the cylinder suddenly increases. The partial derivative equations...

Molecular regulation of macrophages in unleashing cancer-related inflammation

It is unclear how tumor-associated macrophages (TAMs) contribute to the initiation of oncogenesis and how they are regulated at the molecular level. By using a lineage-specific deletion strategy, we found that heat shock protein 90kDa β (Grp94), member 1 (HSP90B1), a master chaperone for Toll-like receptors and integrins also known as GP96, critically endows TAMs with the ability to promote gen...

Heat Shock Proteins and the Regulation of Apoptosis

Since the elucidation of their functions in protein folding and translocation, heat shock protein chaperones have been a target of research in all spheres of biomedicine. Within the last five years, research efforts have intensified, following the discovery of raised levels of heat shock protein (Hsp) expression in the brains of patients suffering from many neurodegenerative disorders, includin...